Blood transfusion history and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis.

ABSTRACT:

Purpose

To conduct a pooled analysis assessing the association of blood transfusion with risk of non-Hodgkin lymphoma (NHL).

Methods

We used harmonized data from 13 case-control studies (10,805 cases, 14,026 controls) in the InterLymph Consortium. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, adjusted for study design variables.

Results

Among non-Hispanic whites (NHW), history of any transfusion was inversely associated with NHL risk for men (OR 0.74; 95% CI 0.65-0.83) but not women (OR 0.92; 95% CI 0.83-1.03), p_{heterogeneity} = 0.014. Transfusion history was not associated with risk in other racial/ethnic groups. There was no trend with the number of transfusions, time since first transfusion, ag

SUBMITTER: Cerhan JR 

PROVIDER: S-EPMC6613988 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature