Pharmacogenetics of alcohol use disorder treatments: an update.

ABSTRACT: Introduction: Alcohol use disorder (AUD) is highly prevalent; costly economically, socially, and interpersonally; and grossly undertreated. The low rate of utilization of medications with demonstrated (albeit modest) efficacy is particularly noteworthy. One approach to increasing the utility and safety of available medications is to use a precision medicine approach, which seeks to identify patients for whom specific medications are likely to be most efficacious and have the fewest adverse effects. Areas Covered: We review the literature on the pharmacogenetics of AUD treatment using both approved and off-label medications. We cover both laboratory studies and clinical trials, highlighting valuable mechanistic insights and underscoring the potential value of precision-based c

SUBMITTER: Hartwell EE 

PROVIDER: S-EPMC6614002 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature