High-fat feeding reprograms maternal energy metabolism and induces long-term postpartum obesity in mice.

ABSTRACT:

Background

Excessive gestational weight gain (EGWG) closely associates with postpartum obesity. However, the causal role of EGWG in postpartum obesity has not been experimentally verified. The objective of this study was to determine whether and how EGWG causes long-term postpartum obesity.

Methods

C57BL/6 mice were fed with high-fat diet during gestation (HFFDG) or control chow, then their body composition and energy metabolism were monitored after delivery.

Results

We found that HFFDG significantly increased gestational weight gain. After delivery, adiposity of HFFDG-treated mice (Preg-HF) quickly recovered to the levels of controls. However, 3 months after parturition, Preg-HF mice started to gain significantly more body fat even with regular chow. The increase of

SUBMITTER: Qiao L 

PROVIDER: S-EPMC6614019 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature