Antisense Transcription in Loci Associated to Hereditary Neurodegenerative Diseases.

ABSTRACT: Natural antisense transcripts are common features of mammalian genes providing additional regulatory layers of gene expression. A comprehensive description of antisense transcription in loci associated to familial neurodegenerative diseases may identify key players in gene regulation and provide tools for manipulating gene expression. We take advantage of the FANTOM5 sequencing datasets that represent the largest collection to date of genome-wide promoter usage in almost 2000 human samples. Transcription start sites (TSSs) are mapped at high resolution by the use of a modified protocol of cap analysis of gene expression (CAGE) for high-throughput single molecule next-generation sequencing with Helicos (hCAGE). Here we present the analysis of antisense transcription at 17 loci associated to

SUBMITTER: Zucchelli S 

PROVIDER: S-EPMC6614138 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature