Chronic Cognitive Deficits and Associated Histopathology Following Closed-Head Concussive Injury in Rats.

ABSTRACT: Close-head concussive injury, as one of the most common forms of traumatic brain injury (TBI), has been shown to induce cognitive deficits that are long lasting. A concussive impact model was previously established in our lab that produces clinically relevant signs of concussion and induced acute pathological changes in rats. To evaluate the long-term effects of repeated concussions in this model, we utilized a comprehensive Morris water maze (MWM) paradigm for cognitive assessments at 1 and 6 months following repeated concussive impacts in rats. As such, adult Sprague-Dawley rats received either anesthesia (sham) or repeated concussive impacts (4 consecutive impacts at 1 h interval). At 1 month post-injury, results of the spatial learning task showed that the average latencies to locate t

SUBMITTER: Deng-Bryant Y 

PROVIDER: S-EPMC6614177 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature