N-terminal pro-B-type natriuretic peptide for predicting fluid challenge in patients with septic shock.

ABSTRACT:

Background

The aim of this study is to examine whether plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration could predict fluid responsiveness in septic shock patients following fluid challenge (FC).

Methods

We reviewed prospectively collected data from 79 septic shock patients who received invasive cardiac output (CO) monitoring following a 500 mL FC. Haemodynamics were recorded, and blood sampling for NT-proBNP values was performed. Patients were divided into responders and non-responders according to fluid responsiveness, which was defined as cardiac index (CI) increase ≥10% induced by FC. The NT-proBNP and the CI changes were analysed using Pearson correlation. The area under the curve (AUC) for NT-proBNP was used to test its ability to distinguish

SUBMITTER: Huang HB 

PROVIDER: S-EPMC6614314 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature