A Peptoid Delivers CoQ-derivative to Plant Mitochondria via Endocytosis.

ABSTRACT: Controlled delivery of molecules interfering specifically with target activities in a cell of interest can be a powerful tool for experimental manipulation, because it can be administered at a defined time point and does not require genetic transformation, which in some systems is difficult and time consuming. Peptides as versatile tools that can be tailored for binding numerous binding partners, are of special interest. However, their passage through membranes, their intracellular targeting, and their sensitivity to proteases is limiting. The use of peptoids, where cationic amino-acid side chains are linked to nitrogen (rather than to carbon) of the peptide bond, can circumvent these limitations, because they are not cleavable by proteases. In the current work, we provide a proof-of-conce

SUBMITTER: Asfaw KG 

PROVIDER: S-EPMC6614412 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature