Drp1 and RB interaction to mediate mitochondria-dependent necroptosis induced by cadmium in hepatocytes.

ABSTRACT: Mitochondrial quality control (MQC) is implicated in cell death induced by heavy metal pollutants. Dynamin-related protein 1 (Drp1) regulates mitochondrial fission, which is an important part of MQC. Retinoblastoma (RB) protein can regulate MQC in a transcription-independent manner. Necroptosis plays a critical role in hepatic pathologies such as inflammatory, infectious, and xenobiotics-induced injury and diseases. We aimed to explore the role and mechanism of Drp1 interaction with RB in hepatocyte's necroptosis caused by cadmium (Cd). CdCl₂ was employed to expose to Institute of Cancer Research (ICR) mice and human hepatic L02 cells. CdCl₂ exposure induced necroptosis and hepatic injury both in vivo and in vitro. Moreover, Drp1 and RB protein were up-regulated and t

SUBMITTER: Zhang S 

PROVIDER: S-EPMC6614419 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature