The adeno-associated virus rh10 vector is an effective gene transfer system for chronic spinal cord injury.

ABSTRACT: Treatment options for chronic spinal cord injury (SCI) remain limited due to unfavourable changes in the microenvironment. Gene therapy can overcome these barriers through continuous delivery of therapeutic gene products to the target tissue. In particular, adeno-associated virus (AAV) vectors are potential candidates for use in chronic SCI, considering their safety and stable gene expression in vivo. Given that different AAV serotypes display different cellular tropisms, it is extremely important to select an optimal serotype for establishing a gene transfer system during the chronic phase of SCI. Therefore, we generated multiple AAV serotypes expressing ffLuc-cp156, a fusion protein of firefly luciferase and Venus, a variant of yellow fluorescent protein with fast and efficient maturatio

SUBMITTER: Hoshino Y 

PROVIDER: S-EPMC6614469 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature