Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders.

ABSTRACT: Platelets are anucleate cells that circulate in blood and are essential components of the hemostatic system. During aging, platelet numbers decrease and their aggregation capacity is reduced. Platelet dysfunctions associated with aging can be linked to molecular alterations affecting several cellular systems that include cytoskeleton rearrangements, signal transduction, vesicular trafficking, and protein degradation. Age platelets may adopt a phenotype characterized by robust secretion of extracellular vesicles that could in turn account for about 70-90% of blood circulating vesicles. Interestingly these extracellular vesicles are loaded with messenger RNAs and microRNAs that may have a profound impact on protein physiology at the systems level. Age platelet dysfunction is also associated

SUBMITTER: Espinosa-Parrilla Y 

PROVIDER: S-EPMC6614495 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature