A reliable Epstein-Barr Virus classification based on phylogenomic and population analyses.

ABSTRACT: The Epstein-Barr virus (EBV) infects more than 90% of the human population, playing a key role in the origin and progression of malignant and non-malignant diseases. Many attempts have been made to classify EBV according to clinical or epidemiological information; however, these classifications show frequent incongruences. For instance, they use a small subset of genes for sorting strains but fail to consider the enormous genomic variability and abundant recombinant regions present in the EBV genome. These could lead to diversity overestimation, alter the tree topology and misinterpret viral types when classified, therefore, a reliable EBV phylogenetic classification is needed to minimize recombination signals. Recombination events occur 2.5-times more often than mutation events, suggestin

SUBMITTER: Zanella L 

PROVIDER: S-EPMC6614506 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature