Functional DNA variations associated with Saudi female with low VO_2max: a pilot microarray study.

ABSTRACT: The study aims to explore the genetic predispositions and molecular pathways of low cardiorespiratory fitness (VO_2max) in young Saudi females (n = 70). Young females were grouped based on the level of VO_2max according to the specification of the physical fitness specialist certification as low VO_2max (< 28.9; n = 19) and high VO_2max (> 33; n = 14) and genotyped for 243345 putative functional exonic variants. The CYFIP2&FNDC9-rs10037485T, C1R-rs75380747G and TOP2A-rs13695C SNPs on chromosome 5, 12 and 17, respectively were found to be the most significant among young Saudi females with low VO_2max (P < 8.01 × 10^-05). Linkage disequilibrium (LD) analysis among the significant SNP

SUBMITTER: Al Asoom LI 

PROVIDER: S-EPMC6614660 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature