Candidate genes and pathways associated with brain metastasis from lung cancer compared with lymph node metastasis.

ABSTRACT: Brain metastasis from lung cancer (BMLC) is one of the common types of metastasis associated with poor prognosis. The aim of the present study was to elucidate the underlying molecular mechanisms of BMLC. The mRNA microarray dataset GSE18549 was downloaded from the Gene Expression Omnibus database. The Limma package of R was used to screen the differentially expressed genes (DEGs). Based on the DAVID database, functional and pathway enrichment analyses of DEGs were performed. Furthermore, the protein-protein interaction (PPI) network was predicted using the STRING database and visualized with Cytoscape software. In addition, hub genes and significant modules were selected based on the network. A total of 190 DEGs with log₂|(fold change)|>1, including 129 significantly downregula

SUBMITTER: Zhao X 

PROVIDER: S-EPMC6614716 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature