Characterization of DSM-IV Opioid Dependence Among Individuals of European Ancestry.

ABSTRACT:

Objective

The opioid epidemic in the United States has led to unprecedented increases in morbidity and mortality, posing a serious public health crisis. Although twin and family studies, as well as genome-wide association studies (GWAS), all identify significant genetic factors contributing to opioid dependence, no studies to date have estimated marker-based heritability estimates of opioid dependence. The goal of the current study was to use a large, genetically imputed, case/control sample of 4,064 participants (after quality control and imputation) with genome-wide data to estimate the unbiased heritability tagged by single nucleotide polymorphisms (SNPs).

Method

Study data were part of the Genome-wide Study of Heroin Dependence obtained via the Database for Genotypes and

SUBMITTER: Brick LA 

PROVIDER: S-EPMC6614928 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature