Prenatal particulate air pollution exposure and sleep disruption in preschoolers: Windows of susceptibility.

ABSTRACT:

Background

The programming of sleep architecture begins in pregnancy and depends upon optimal in utero formation and maturation of the neural connectivity of the brain. Particulate air pollution exposure can disrupt fetal brain development but associations between fine particulate matter (PM_2.5) exposure during pregnancy and child sleep outcomes have not been previously explored.

Methods

Analyses included 397 mother-child pairs enrolled in a pregnancy cohort in Mexico City. Daily ambient prenatal PM_2.5 exposure was estimated using a validated satellite-based spatio-temporally resolved prediction model. Child sleep periods were estimated objectively using wrist-worn, continuous actigraphy over a 1-week period at age 4-5 years. Data-driven advanced statis

SUBMITTER: Bose S 

PROVIDER: S-EPMC6615028 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature