Differential response of esophageal cancer cells to particle irradiation.

ABSTRACT:

Background

Radiation therapy is a mainstay in the treatment of esophageal cancer (EC) patients, and photon radiotherapy has proved beneficial both in the neoadjuvant and the definitive setting. However, regarding the still poor prognosis of many EC patients, particle radiation employing a higher biological effectiveness may help to further improve patient outcomes. However, the influence of clinically available particle radiation on EC cells remains largely unknown.

Methods

Patient-derived esophageal adenocarcinoma and squamous cell cancer lines were treated with photon and particle irradiation using clinically available proton (¹H), carbon (¹²C) or oxygen (¹⁶O) beams at the Heidelberg Ion Therapy Center. Histology-dependent clonogenic surviv

SUBMITTER: Hartfiel S 

PROVIDER: S-EPMC6615091 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature