Landmark models to define the age-adjusted risk of developing stage 1 type 1 diabetes across childhood and adolescence.

ABSTRACT:

Background

Autoimmune diseases are often preceded by an asymptomatic autoantibody-positive phase. In type 1 diabetes, the detection of autoantibodies to pancreatic islet antigens in genetically at-risk children is prognostic for future clinical diabetes. Testing for islet autoantibodies is, therefore, performed in a range of clinical studies. Accurate risk estimates that consider the a priori genetic risk and other risk modifiers are an important component of screening. The age of an individual is an under-appreciated risk modifier. The aim of this study was to provide age-adjusted risk estimates for the development of autoantibodies across childhood in genetically at-risk children.

Methods

The prospective BABYDIAB and BABYDIET studies included 2441 children from birth who h

SUBMITTER: Hoffmann VS 

PROVIDER: S-EPMC6615150 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature