Microarray analysis of infectious bronchitis virus infection of chicken primary dendritic cells.

ABSTRACT:

Background

Avian infectious bronchitis virus (IBV) is a major respiratory disease-causing agent in birds that leads to significant losses. Dendritic cells (DCs) are specialised cells responsible for sampling antigens and presenting them to T cells, which also play an essential role in recognising and neutralising viruses. Recent studies have suggested that non-coding RNAs may regulate the functional program of DCs. Expression of host non-coding RNAs changes markedly during infectious bronchitis virus infection, but their role in regulating host immune function has not been explored. Here, microarrays of mRNAs, miRNAs, and lncRNAs were globally performed to analyse how avian DCs respond to IBV.

Results

First, we found that IBV stimulation did not enhance the maturation abilit

SUBMITTER: Lin J 

PROVIDER: S-EPMC6615177 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature