The challenges of gout flare reporting: mapping flares during a randomized controlled trial.

ABSTRACT:

Background

Methods of gout flare reporting in research settings are inconsistent and poorly defined. The aim of this study was to describe patterns of gout flare and assess the concurrent validity of different methods of flare reporting in a gout clinical trial.

Methods

Daily flare diary entries including self-report of flare and pain scale from a randomised controlled trial of 120 patients with gout were analysed. Detailed pain-by-time plots for each participant were inspected and analysed for different methods of flare reporting for both self-report and the classification tree (CART)-defined flare developed by Gaffo in 2012. Concurrent validity for different methods of flare reporting were analysed.

Results

Although the single gout flare had a 'typical' average patt

SUBMITTER: Teoh N 

PROVIDER: S-EPMC6615178 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature