COL6A3 polymorphisms were associated with lung cancer risk in a Chinese population.

ABSTRACT:

Background

Lung cancer is one of the leading cause of cancer-related death in the world. Recently, many clinical researches have reported that COL6A3 had strong role in many diseases. The aim of this study was to evaluate the association between single nucleotide polymorphisms (SNPs) in COL6A3 and lung cancer susceptibility.

Method

Eight variants in COL6A3 were genotyped in a Chinese Han population including 510 cases and 495 controls using Agena MassARRAY. Genetic models and haplotype analyses were used to calculate the association between COL6A3 SNPs and lung cancer risk. And we assessed the relative risk by the odds ratio (OR) and 95% confidence interval (CI).

Results

In our results, we observed that rs115510139 was linked to an increased risk of lung cancer in the

SUBMITTER: Duan Y 

PROVIDER: S-EPMC6615180 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature