Plasma IL-5 but Not CXCL13 Correlates With Neutralization Breadth in HIV-Infected Children.

ABSTRACT: Children may be the optimal target for HIV vaccine development as they generate substantially more frequent and more potent broadly HIV neutralizing antibodies (bnAbs) than adults. Development of a biomarker that correlates with neutralization breadth in this group could function as a powerful tool to facilitate the development of an HIV vaccine. Previously, we observed that this preferential ability in HIV-infected children over adults to generate bnAbs is associated with an enrichment of circulating follicular helper T-cells (T_FH) with an effector phenotype, and the presence of IL-21 secreting HIV-specific T_FH within lymphoid tissue germinal centers (GC). In adults, bnAbs development has been linked with high plasma levels of CXCL13, a chemoattractant for CXCR5-expr

SUBMITTER: Roider J 

PROVIDER: S-EPMC6615198 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature