Flubendazole demonstrates valid antitumor effects by inhibiting STAT3 and activating autophagy.

ABSTRACT:

Background

Signal transducer and activator of transcription 3 (STAT3) is an oncogene, which upregulates in approximately 70% of human cancers. Autophagy is an evolutionarily conserved process which maintains cellular homeostasis and eliminates damaged cellular components. Moreover, the STAT3 signaling pathway, which may be triggered by cancer cells, has been implicated in the autophagic process.

Methods

In this study, we found that the anthelmintic flubendazole exerts potent antitumor activity in three human colorectal cancer (CRC) cell lines and in the nude mouse model. The inhibition of cell proliferation in vitro by flubendazole was evaluated using a clonogenic assay and the MTT assay. Western blot analysis, flow cytometry analysis, siRNA growth experiment and cytoplasmic

SUBMITTER: Lin S 

PROVIDER: S-EPMC6615228 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature