Systematic identification of intergenic long-noncoding RNAs in mouse retinas using full-length isoform sequencing.

ABSTRACT:

Background

A great mass of long noncoding RNAs (lncRNAs) have been identified in mouse genome and increasing evidences in the last decades have revealed their crucial roles in diverse biological processes. Nevertheless, the biological roles of lncRNAs in the mouse retina remains largely unknown due to the lack of a comprehensive annotation of lncRNAs expressed in the retina.

Results

In this study, we applied the long-reads sequencing strategy to unravel the transcriptomes of developing mouse retinas and identified a total of 940 intergenic lncRNAs (lincRNAs) in embryonic and neonatal retinas, including about 13% of them were transcribed from unannotated gene loci. Subsequent analysis revealed that function of lincRNAs expressed in mouse retinas were closely related to the ph

SUBMITTER: Wan Y 

PROVIDER: S-EPMC6615288 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature