B-Vitamin Sharing Promotes Stability of Gut Microbial Communities.

ABSTRACT: Cross-feeding on intermediary and end-point metabolites plays an important role in the dynamic interactions of host-associated microbial communities. While gut microbiota possess inherent resilience to perturbation, variations in the intake of certain nutrients may lead to changes in the community composition with potential consequences on host physiology. Syntrophic relationships and mutualism at the level of major carbon and energy sources have been documented, however, relatively little is known about metabolic interactions involving micronutrients, such as B-vitamins, biosynthetic precursors of essential cofactors in the mammalian host and numerous members of the gut microbiota alike. In silico genomic reconstruction and prediction of community-wide metabolic phenotypes for eigh

SUBMITTER: Sharma V 

PROVIDER: S-EPMC6615432 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature