Epidemiology of Clostridioides difficile infection in Canada: A six-year review to support vaccine decision-making.

ABSTRACT:

Background

Two vaccines against Clostridioides difficile infections (CDI) are currently in phase III trials. To enable decision-making on their use in public health programs, national disease epidemiology is necessary.

Objectives

To determine the epidemiology of hospital-acquired CDI (HA-CDI) and community-associated CDI (CA-CDI) in Canada using provincial surveillance data and document discrepancies in CDI-related definitions among provincial surveillance programs.

Methods

Publicly-available CDI provincial surveillance data from 2011 to 2016 that distinguished between HA-CDI and CA-CDI were included and the most common surveillance definitions for each province were used. The HA-, CA-CDI incidence rates and CA-CDI proportions (%) were calculated for each provi

SUBMITTER: Xia Y 

PROVIDER: S-EPMC6615439 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature