The Ca_V1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear.

ABSTRACT: Bone remodeling of the auditory ossicles and the otic capsule is highly restricted and tightly controlled by the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa-Β ligand (RANKL)/receptor activator of nuclear factor kappa-Β (RANK) system. In these bony structures, a pathological decrease in OPG expression stimulates osteoclast differentiation and excessive resorption followed by accrual of sclerotic bone, ultimately resulting in the development of otosclerosis, a leading cause of deafness in adults. Understanding the signaling pathways involved in maintaining OPG expression in the ear would shed light on the pathophysiology of otosclerosis and other ear bone-related diseases. We and others previously demonstrated that Ca²⁺ signaling through the L-type Ca_V

SUBMITTER: Cao C 

PROVIDER: S-EPMC6615562 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature