Estimating minute ventilation and air pollution inhaled dose using heart rate, breath frequency, age, sex and forced vital capacity: A pooled-data analysis.

ABSTRACT: Air pollution inhaled dose is the product of pollutant concentration and minute ventilation ([Formula: see text]). Previous studies have parameterized the relationship between [Formula: see text] and variables such as heart rate (HR) and have observed substantial inter-subject variability. In this paper, we evaluate a method to estimate [Formula: see text] with easy-to-measure variables in an analysis of pooled-data from eight independent studies. We compiled a large diverse data set that is balanced with respect to age, sex and fitness level. We used linear mixed models to estimate [Formula: see text] with HR, breath frequency (fB), age, sex, height, and forced vital capacity (FVC) as predictors. FVC was estimated using the Global Lung Function Initiative method. We log-transformed the de

SUBMITTER: Greenwald R 

PROVIDER: S-EPMC6615621 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature