Comparison of intra- and inter-host genetic diversity in rabies virus during experimental cross-species transmission.

ABSTRACT: The development of high-throughput genome sequencing enables accurate measurements of levels of sub-consensus intra-host virus genetic diversity and analysis of the role played by natural selection during cross-species transmission. We analysed the natural and experimental evolution of rabies virus (RABV), an important example of a virus that is able to make multiple host jumps. In particular, we (i) analyzed RABV evolution during experimental host switching with the goal of identifying possible genetic markers of host adaptation, (ii) compared the mutational changes observed during passage with those observed in natura, and (iii) determined whether the colonization of new hosts or tissues requires adaptive evolution in the virus. To address these aims, animal infection models (dog and fox

SUBMITTER: Bonnaud EM 

PROVIDER: S-EPMC6615636 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature