Nasal high-flow versus noninvasive ventilation in patients with chronic hypercapnic COPD.

ABSTRACT:

Background

Despite the encouraging results of noninvasive ventilation (NIV) in chronic hypercapnic COPD patients, it is also evident that some patients do not tolerate NIV or do not benefit from it. We conducted a study in which COPD patients with stable, chronic hypercapnia were treated with NIV and nasal high-flow (NHF) to compare effectiveness.

Methods

In a multi-centered, randomized, controlled, cross-over design, patients received 6 weeks of NHF ventilation followed by 6 weeks of NIV ventilation or vice-versa (TIBICO) between 2011 and 2016. COPD patients with stable daytime hypercapnia (pCO₂≥50 mmHg) were recruited from 13 German centers. The primary endpoint was pCO₂ changes from baseline blood gas, lung function, quality of life (QoL), the 6 min

SUBMITTER: Braunlich J 

PROVIDER: S-EPMC6615713 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature