Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort.

ABSTRACT: Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analysed by mass spectrometry after digestion in nitric acid and peroxi

SUBMITTER: Cassoulet R 

PROVIDER: S-EPMC6615730 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature