Epigenetic Compensation Promotes Liver Regeneration.

ABSTRACT: Two major functions of the epigenome are to regulate gene expression and to suppress transposons. It is unclear how these functions are balanced during physiological challenges requiring tissue regeneration, where exquisite coordination of gene expression is essential. Transcriptomic analysis of seven time points following partial hepatectomy identified the epigenetic regulator UHRF1, which is essential for DNA methylation, as dynamically expressed during liver regeneration in mice. UHRF1 deletion in hepatocytes (Uhrf1^HepKO) caused genome-wide DNA hypomethylation but, surprisingly, had no measurable effect on gene or transposon expression or liver homeostasis. Partial hepatectomy of Uhrf1^HepKO livers resulted in early and sustained activation of proregenerative genes

SUBMITTER: Wang S 

PROVIDER: S-EPMC6615735 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature