A tailored approach towards informing relatives at risk of inherited cardiac conditions: study protocol for a randomised controlled trial.

ABSTRACT:

Introduction

In current practice, probands are asked to inform relatives about the possibility of predictive DNA testing when a pathogenic variant causing an inherited cardiac condition (ICC) is identified. Previous research on the uptake of genetic counselling and predictive DNA testing in relatives suggests that not all relatives are sufficiently informed. We developed a randomised controlled trial to evaluate the effectiveness of a tailored approach in which probands decide together with the genetic counsellor which relatives they inform themselves and which relatives they prefer to have informed by the genetic counsellor. Here, we present the study protocol of this randomised controlled trial.

Methods

A multicentre randomised controlled trial with parallel-group design w

SUBMITTER: van den Heuvel LM 

PROVIDER: S-EPMC6615798 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature