Risk of amyotrophic lateral sclerosis and other motor neuron disease among men with benign prostatic hyperplasia: a population-based cohort study.

ABSTRACT:

Objectives

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder. Sleep disturbance may interfere with clearance of abnormal proteins that aggregate in neurodegenerative diseases. The objective of this study was to examine the association between benign prostatic hyperplasia (BPH), a common disorder causing nocturia and sleep disturbance, and risk of ALS and other motor neuron disease (MND). We hypothesised that men with BPH, in comparison to men in the general population, would be at increased risk.

Design

This is a nationwide, population-based cohort study.

Setting

This study was conducted among the population of Denmark.

Participants

We used linked Danish medical databases to identify all men with a first-time diagnosis of B

SUBMITTER: Sorensen TT 

PROVIDER: S-EPMC6615877 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature