Helios Deficiency Predisposes the Differentiation of CD4⁺Foxp3^- T Cells into Peripherally Derived Regulatory T Cells.

ABSTRACT: The transcription factor Helios is expressed in a large percentage of Foxp3⁺ regulatory T (Treg) cells and is required for the maintenance of their suppressive phenotype, as mice with a selective deficiency of Helios in Treg cells spontaneously develop autoimmunity. However, mice with a deficiency of Helios in all T cells do not exhibit autoimmunity, despite the defect in the suppressor function of their Treg cell population, suggesting that Helios also functions in non-Treg cells. Although Helios is expressed in a small subset of CD4⁺Foxp3^- and CD8⁺ T cells and its expression is upregulated upon T cell activation, its function in non-Treg cells remains unknown. To examine the function of Helios in CD4⁺Foxp3^- T cells, we tra

SUBMITTER: Skadow M 

PROVIDER: S-EPMC6615958 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature