Implantable antimicrobial biomaterials for local drug delivery in bone infection models.

ABSTRACT: Increased use of implantable biomedical devices demonstrates their potential in treating a wide variety of ailments and disorders in bone trauma and orthopaedic, reconstructive, and craniofacial applications. However, the number of cases involving implant failure or malfunction due to bacterial infection have also increased in recent years. Implanted devices can facilitate the growth of bacteria as these micro-organisms have the potential to adhere to the implant and grow and develop to form biofilms. In an effort to better understand and mitigate these occurrences, biomaterials containing antimicrobial agents that can be released or presented within the local microenvironment have become an important area of research. In this review, we discuss critical factors that regulate antimicrobial

SUBMITTER: Caplin JD 

PROVIDER: S-EPMC6615972 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature