Metformin Inhibits the Type 1 IFN Response in Human CD4⁺ T Cells.

ABSTRACT: In systemic lupus erythematosus, defective clearance of apoptotic debris and activation of innate cells result in a chronically activated type 1 IFN response, which can be measured in PBMCs of most patients. Metformin, a widely used prescription drug for Type 2 diabetes, has a therapeutic effect in several mouse models of lupus through mechanisms involving inhibition of oxidative phosphorylation and a decrease in CD4⁺ T cell activation. In this study, we report that in CD4⁺ T cells from human healthy controls and human systemic lupus erythematosus patients, metformin inhibits the transcription of IFN-stimulated genes (ISGs) after IFN-α treatment. Accordingly, metformin inhibited the phosphorylation of pSTAT1 (Y701) and its binding to IFN-stimulated response elements t

SUBMITTER: Titov AA 

PROVIDER: S-EPMC6615983 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature