A population-based survey of gastroesophageal reflux disease in a region with high prevalence of esophageal cancer in China.

ABSTRACT:

Background

The exact relationship between gastroesophageal reflux disease (GERD) and esophageal squamous cell cancer (ESCC) is far from clarification. The aim of this study was to investigate the epidemiology of GERD in a region with high prevalence of ESCC in China.

Methods

A population-based, cross-sectional study was conducted in a high ESCC prevalent area, Anyang, Henan, China. All subjects fulfilled questionnaires and underwent gastroendoscopy with routine esophageal biopsy. The subjects were divided into GERD subtypes (reflux esophagitis [RE] and non-erosive reflux disease [NERD]) and controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to examine risk factors for RE and NERD.

Results

A total of 2844 subjects were finally enrolled. The

SUBMITTER: Wang K 

PROVIDER: S-EPMC6616241 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature