CAMK2-Dependent Signaling in Neurons Is Essential for Survival.

ABSTRACT: Ca²⁺/calmodulin-dependent protein kinase II (CAMK2) is a key player in synaptic plasticity and memory formation. Mutations in Camk2a or Camk2b cause intellectual disability in humans, and severe plasticity and learning deficits in mice, indicating unique functions for each isoform. However, considering the high homology between CAMK2A and CAMK2B, it is conceivable that for critical functions, one isoform compensates for the absence of the other, and that the full functional spectrum of neuronal CAMK2 remains to be revealed.Here we show that germline as well as adult deletion of both CAMK2 isoforms in male or female mice is lethal. Moreover, Ca²⁺-dependent activity as well as autonomous activity of CAMK2 is essential for survival. Loss of both CAMK2 isofo

SUBMITTER: Kool MJ 

PROVIDER: S-EPMC6616294 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature