Limiting Neuronal Nogo Receptor 1 Signaling during Experimental Autoimmune Encephalomyelitis Preserves Axonal Transport and Abrogates Inflammatory Demyelination.

ABSTRACT: We previously identified that ngr1 allele deletion limits the severity of experimental autoimmune encephalomyelitis (EAE) by preserving axonal integrity. However, whether this favorable outcome observed in EAE is a consequence of an abrogated neuronal-specific pathophysiological mechanism, is yet to be defined. Here we show that, Cre-loxP-mediated neuron-specific deletion of ngr1 preserved axonal integrity, whereas its re-expression in ngr1^-/- female mice potentiated EAE-axonopathy. As a corollary, myelin integrity was preserved under Cre deletion in ngr1^flx/flx , retinal ganglion cell axons whereas, significant demyelination occurred in the ngr1^-/- optic nerves following the re-introduction of NgR1. Moreover, Cre-loxP-med

SUBMITTER: Lee JY 

PROVIDER: S-EPMC6616297 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature