The contribution of parent-to-offspring transmission of telomeres to the heritability of telomere length in humans.

ABSTRACT: Leukocyte telomere length (LTL) is a heritable trait with two potential sources of heritability (h²): inherited variation in non-telomeric regions (e.g., SNPs that influence telomere maintenance) and variability in the lengths of telomeres in gametes that produce offspring zygotes (i.e., "direct" inheritance). Prior studies of LTL h² have not attempted to disentangle these two sources. Here, we use a novel approach for detecting the direct inheritance of telomeres by studying the association between identity-by-descent (IBD) sharing at chromosome ends and phenotypic similarity in LTL. We measured genome-wide SNPs and LTL for a sample of 5069 Bangladeshi adults with substantial relatedness. For each of the 6318 relative pairs identified, we used SNPs near the telomeres

SUBMITTER: Delgado DA 

PROVIDER: S-EPMC6616344 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature