The association between adherence with oral bisphosphonates and the risk of breast cancer in post-menopausal women.

ABSTRACT:

Background

Several observational studies have suggested a protective effect of oral bisphosphonates (BP) on the risk of breast cancer, but no such association has been seen in randomized control trials. The role of oral BP in breast cancer prevention remains unclear.

Aim

To investigate the association between different levels of BP exposure and breast cancer incidence in a cohort of osteoporotic post-menopausal women.

Subjects and methods

This historical prospective study was conducted using the computerized databases of Maccabi Healthcare Services (MHS) in Israel. Included in the study were osteopenic and osteoporotic women aged 55-75 years who started BP therapy between 1998 and 2012. The subjects were enrolled in MHS for at least 3 years before therapy initiation,

SUBMITTER: Rouach V 

PROVIDER: S-EPMC6616345 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature