Two Insertion/Deletion Variants within SPAG17 Gene Are Associated with Goat Body Measurement Traits.

ABSTRACT: Sperm-associated antigen 17 (SPAG17) gene encodes a multifunctional cytoplasmic protein, which influences not only reproduction but also skeletal development related body measurement traits, especially body height. Thus, this study aimed to identify crucial insertion-deletion (indel) variations, which influence the body measurement traits of goats in large goat populations (n = 1725). As a result, two intronic indels (14 bp and 17 bp indel) were identified by sequencing. For the two indel loci, the distributions of genotypes and alleles were significantly different between the Shaanbei white cashmere goat (SBWC) and the Hainan black goat (HNBG). In SBWC goats, the different genotypes of the 14 bp indel were markedly associated with goat body height, chest width, body length and chest depth

SUBMITTER: Zhang S 

PROVIDER: S-EPMC6616450 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature