A New Genome-to-Genome Comparison Approach for Large-Scale Revisiting of Current Microbial Taxonomy.

ABSTRACT: Microbial diversity has always presented taxonomic challenges. With the popularity of next-generation sequencing technology, more unculturable bacteria have been sequenced, facilitating the discovery of additional new species and complicated current microbial classification. The major challenge is to assign appropriate taxonomic names. Hence, assessing the consistency between taxonomy and genomic relatedness is critical. We proposed and applied a genome comparison approach to a large-scale survey to investigate the distribution of genomic differences among microorganisms. The approach applies a genome-wide criterion, homologous coverage ratio (HCR), for describing the homology between species. The survey included 7861 microbial genomes that excluded plasmids, and 1220 pairs of genera exhib

SUBMITTER: Tsai MH 

PROVIDER: S-EPMC6616886 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature