MicroRNA Profile of HCV Spontaneous Clarified Individuals, Denotes Previous HCV Infection.

ABSTRACT: Factors involved in the spontaneous cleareance of a hepatitis C (HCV) infection are related to both HCV and the interaction with the host immune system, but little is known about the consequences after a spontaneous resolution. The main HCV extrahepatic reservoir is the peripheral blood mononuclear cells (PBMCs), and their transcriptional profile provides us information of innate and adaptive immune responses against an HCV infection. MicroRNAs regulate the innate and adaptive immune responses, and they are actively involved in the HCV cycle. High Throughput sequencing was used to analyze the miRNA profiles from PBMCs of HCV chronic naïve patients (CHC), individuals that spontaneously clarified HCV (SC), and healthy controls (HC). We did not find any differentially expressed miRNAs between

SUBMITTER: Brochado-Kith O 

PROVIDER: S-EPMC6617112 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature