Accurate outcome prediction after neo-adjuvant radio-chemotherapy for rectal cancer based on a TCP-based early regression index.

ABSTRACT:

Background and purpose

An early tumor regression index (ERI_TCP) was previously introduced and found to predict pathological response after neo-adjuvant radio-chemotherapy of rectal cancer. ERI_TCP was tested as a potential biomarker in predicting long-term disease-free survival.

Materials and methods

Data of 65 patients treated with an early regression-guided adaptive boosting technique (ART) were available. Overall, loco-regional relapse-free and distant metastasis-free survival (OS, LRFS, DMFS) were considered. Patients received 41.4 Gy in 18 fractions (2.3 Gy/fr), including ART concomitant boost on the residual GTV during the last 6 fractions (3 Gy/fr, D_mean: 45.6 Gy). Chemotherapy included oxaliplatin and 5-fluorouracil (5-FU). T2-weighted

SUBMITTER: Fiorino C 

PROVIDER: S-EPMC6617292 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature