Prognostic biomarkers of cervical squamous cell carcinoma identified via plasma metabolomics.

ABSTRACT: Cervical cancer is the second most common female malignancy worldwide. The metabolic profile of plasma associated with the prognosis of cervical cancer remains poorly understood. In this cross-sectional study, plasma samples were collected from three groups of patients with CSCC, namely primary patients before treatment (BT group), patients with a poor prognosis (PP group, including patients with distant metastasis and local recurrence), and patients with a good prognosis within two years after the first treatment (GP group). The plasma metabolomics was conducted to detect the dynamic changes of metabolites via ultra-performance liquid chromatography with quadrupole time-of-flight mass spectrometry. Multivariate analyses, including principle component, partial least square-discriminant, an

SUBMITTER: Zhou H 

PROVIDER: S-EPMC6617423 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature