Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing.

ABSTRACT: Fibrosis accompanying wound healing can drive the failure of many different organs. Activated fibroblasts are the principal determinants of post-injury pathological fibrosis along with physiological repair, making them a difficult therapeutic target. Although activated fibroblasts are phenotypically heterogeneous, they are not recognized as distinct functional entities. Using mice that express GFP under the FSP1 or αSMA promoter, we characterized two non-overlapping fibroblast subtypes from mouse hearts after myocardial infarction. Here, we report the identification of FSP1-GFP⁺ cells as a non-pericyte, non-hematopoietic fibroblast subpopulation with a predominant pro-angiogenic role, characterized by in vitro phenotypic/cellular/ultrastructural studies and in vivo granulation t

SUBMITTER: Saraswati S 

PROVIDER: S-EPMC6617456 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature