A systematic approach to orient the human protein-protein interaction network.
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ABSTRACT:
SUBMITTER: Silverbush D
PROVIDER: S-EPMC6617457 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
A systematic approach to orient the human protein-protein interaction network.
Silverbush Dana D Sharan Roded R
Nature communications 20190709 1
The protein-protein interaction (PPI) network of an organism serves as a skeleton for its signaling circuitry, which mediates cellular response to environmental and genetic cues. Understanding this circuitry could improve the prediction of gene function and cellular behavior in response to diverse signals. To realize this potential, one has to comprehensively map PPIs and their directions of signal flow. While the quality and the volume of identified human PPIs improved dramatically over the las ...[more]
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