Role of integrative structural biology in understanding transcriptional initiation.

ABSTRACT: Integrative structural biology combines data from multiple experimental techniques to generate complete structural models for the biological system of interest. Most commonly cross-linking data sets are employed alongside electron microscopy maps, crystallographic structures, and other data by computational methods that integrate all known information and produce structural models at a level of resolution that is appropriate to the input data. The precision of these modelled solutions is limited by the sparseness of cross-links observed, the length of the cross-linking reagent, the ambiguity arisen from the presence of multiple copies of the same protein, and structural and compositional heterogeneity. In recent years integrative structural biology approaches have been successfully applied

SUBMITTER: Trnka MJ 

PROVIDER: S-EPMC6617507 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature