Chronic exposure to high fat diet triggers myelin disruption and interleukin-33 upregulation in hypothalamus.

ABSTRACT:

Background

Hypothalamic inflammation including astrogliosis and microglia activation occurs after intake of high fat diet (HFD) in rodent models or in obese individuals. However, the effect of chronic HFD feeding on oligodendrocytes (OLGs), a myelin-producing glial population in the central nervous system (CNS), remains unclear. In this study, we used 8-week old male C57BL/6 mice fed by HFD for 3-6 months to induce chronic obesity.

Results

The transmission electron microscopy imaging analysis showed that the integrity of hypothalamic myelin was disrupted after HFD feeding for 4 and 6 months. Moreover, the accumulation of Iba1⁺-microglia with an amoeboid hypertrophic form was continually observed in arcuate nucleus of HFD-fed mice during the entire feeding time per

SUBMITTER: Huang HT 

PROVIDER: S-EPMC6617565 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature